HC-AZ Combo for COVID-19: Suggested Protocol

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Do not proceed with any medical treatment without first seeking guidance of a medical professional.

Recommended dosing:

Hydroxychloroquine (HC) 200 mg po TID for 5 days

Azithromycin (AZ) 500 mg po day 1 and then 250 mg po days 2 – 5

Who should be treated:

All COVID-19 positive patients

  • Regardless of symptoms
  • Not necessary if previously positive and are now COVID-19 negative (defined by two negative PCR tests 24 hours apart)
  • If feasible (obvious special circumstances will occur: critically ill hospitalized patients, unable to take oral medications, allergy to one or more of the medications, potential drug interactions – which are minimal). These will have to be on a case by case basis.

Post-exposure prophylaxis (PEP) for high risk exposures

  • Health care workers
  • Household contacts
  • First responders, law enforcement, etc.
  • High risk community or facility clusters (e.g. nursing homes, church with “super-spreader”)

Basis for these recommendations:

  • Compelling in vitro data showing potent antiviral effects of chloroquine and HC (Vincent 2005, Keyaerts 2004, Yao 2020)
  • Open-label clinical trial from France (Gualtret 2020)
  • Rapidly growing real time experience world-wide
  • These drugs have a good safety profile

Joseph Brewer M.D., Plaza Infectious Disease and St. Luke’s Hospital, Kansas City. 

March 20, 2020

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